NIBB-Academia Sinica International Webinar of Aquatic Model Organisms for Basic Biology to Human Disease Models

Speaker: Dr. Ken-ichi T. Suzuki

Institute: Center for the Development of New Model Organisms, National Institute for Basic Biology, Okazaki, Japan

Talk title: Involvement of thyroid hormone receptors in the transition from larval-to adult-type organs in Xenopus metamorphosis

Organ remodeling from the larval- to adult-type occurs under the control of thyroid hormone (TH) and its receptors (TRs) signaling during amphibian metamorphosis. However, it still remains unclear how TH/TRs regulate the metamorphic remodeling. To address this issue directly, we examined the involvement of TRs in Xenopus metamorphosis using CRISPR/Cas9 based knock-out.